The mechanism of action is unknown. It is thought that Procyclidine acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Many of its effects are due to its pharmacologic similarities with Procyclidine Hydrochloride is the hydrochloride salt form of procyclidine, with anticholinergic properties. Procyclidine hydrochloride competitively binds to striatal cholinergic receptors, thereby diminishing acetylcholine activity and ultimately reducing the frequency and severity of akinesia, rigidity, and tremor associated with uncontrollable body movements. Mechanism of action The normal inhibition of cholinergic neurotransmission in the caudate and putamen by DA is blocked by AP drugs. This leads to a relative excess of cholinergic neurotransmission and may cause acute dystonia and parkinsonism. By: Flavio Guzman, MD. Olanzapine is a second-generation antipsychotic that acts as antagonist at 5HT2A and D2 receptors. Mechanism of Action. The mechanism of action of olanzapine, as with other drugs having efficacy in schizophrenia, is unknown. Mechanism of Action Description: Procyclidine is postulated to act by blocking excess acetylcholine at the muscarinic receptor; many of its effects are due to its pharmacologic similarities w/ atropine. Procyclidine is also sometimes used for the treatment of dystonia (but not tardive dyskinesia), a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face. Mechanism of action/Effect: Specific mode of action is unknown, but it is thought that these agents partially block central (striatal) cholinergic receptors, thereby helping to balance cholinergic and dopaminergic activity 09 in the basal ganglia; salivation may be decreased 10 12 20 , and smooth muscle may be relaxed. Procyclidine About Procyclidine Anticholinergic, Anti-Parkinson`s Agent, Antispasmodic. Mechanism of Action of Procyclidine The exact mechanism of action is not known. Mechanism of action Procyclidine is a synthetic anticholinergic agent which blocks the excitatory effects of acetylcholine at the muscarinic receptor. Idiopathic Parkinson's disease is thought to result from degeneration of neurones in the substantia nigra whose axons project and inhibit cells in the corpus striatum. Procyclidine Hydrochloride reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI).